Week 6 NFL Odds - Buffalo Bills at Arizona Cardinals

Bet on the NFLLate on Sunday afternoon, the Buffalo Bills leave the Northeast for the Southwest as they travel to Arizona to take on the Cardinals. The game in the U of Phoenix Stadium in Glendale, AZ is scheduled to kick off at 4:05 PM ET, and will be televised regionally on CBS.

The Bills became another casualty of the San Francisco 49ers, losing 45-3. Buffalo barely showed up in this one, allowing the Niners to set a franchise record with 621 yards of offense. The Bills, on the other hand, could manage just 204 total yards. The 49ers held a 311-89 edge in rushing yards, and kept possession of the ball for 13 more minutes than Buffalo. The Bills also coughed it up twice, losing a fumble and throwing an interception. QB Ryan Fitzpatrick threw 16-of-26, for 126 yards. Over the last two weeks, the Bills have allowed 580 and 621 yards, along with 62 first downs. In the last 6 quarters of play, they have been outscored 90-10.

The Cardinals come into this game off of a tough loss in St. Louis to the Rams, 17-3. This was a 15-point spread loss for AZ. The Rams sacked Cards QB Kevin Kolb 9 times, while not allowing a single touchdown from Arizona. Despite this, the Cardinals won the stats game, holding a 20-12 edge in first downs, and a 282-242 edge in offensive yards. Those 9 sacks cost Arizona 52 yards, with 5 penalties costing them 35 more. QB Kolb threw 28-of-50, for 289 yards. In 3 of their 5 games this season, the Cardinals have tallied fewer than 46 rushing yards.

Buffalo is 2-3 ATS on the season so far, and 0-2 ATS as the away underdog. The dog is on a 9-1-1 spread run in Arizona games. The Cardinals are 2-16 ATS coming off of a double-digit SU loss against an opponent coming off a similar double-digit SU loss. How's that for a stat? On the season, the Cards are 3-2 ATS, and are 0-1 ATS as a home favorite.

These two teams have met just twice since 2001, with the series tied at a game apiece. Their last meeting, in October 2008, resulted in a 41-17 Cardinals victory. In that one, Arizona was a 1 ½ point favorite. In an October 2004 matchup, Buffalo won 38-14, after the Bills were 4 point favorites.

For this Sunday's game, the Bet Royal Sportsbook odds list the Cardinals as 4 ½ point home favorites. The over/under is set at 43 ½ points.

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Click here to read our Chiefs-Bills odds preview from Week 2 of the regular season. We also looked at the Bills-Jets game in Week 1, which you can read on this page. If you're a Cardinals fan, go here to read our Arizona-New England trends preview from Week 2. We also previewed the Seahawks-Cardinals game from Week 1 in this article.