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Bet on the NFLThe San Francisco 49ers have held a good advantage against their NFC West rivals in the Arizona Cardinals in recent time. However, the Cardinals have won their first two games unlike the 49ers. However, a significant injury might end up putting a wrench in the Cardinals' game as they host the 49ers at University of Phoenix Stadium in Glendale.

The 49ers have won nine of their last ten games against the Cardinals. The last match between the two was close as the Niners won 23-20 back in December, thus going past a +3 spread. The Cardinals have not beaten the Niners since December 2011. The over has gone in four of their last five games. The 49ers are also 7-1 ATS in their last few games in Arizona.

The Cardinals have won five of their last six straight up regular season games and have gone 4-2 ATS in those games. Their last one was a 25-14 win over the New York Giants this past weekend. The Cardinals were listed at +1 to win that game and almost reached the 41.5 over/under for the game. There are extreme doubts if Cardinals quarterback Carson Palmer will play this weekend due to a shoulder injury, thus prompting Drew Stanton to come in. The Cardinals have gone under the point total in their last five September games.

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The 49ers lost their last game as they were leading the Chicago Bears for a while but fell 28-20 in the end. The Niners had a -7 line for the game. The team has gone under the point total in their last four road games and are 6-1 ATS against road teams with winning records in recent history.

The San Francisco 49ers have a very minor edge for this week's game. The team has a -3 advantage to win this week's game. The over/under for points is listed at 42 for the day. The straight up lines are also very close as the Cardinals have a +140 line while the Niners are at -160.


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