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Bet on the NFLLate on Sunday afternoon, the Buffalo Bills leave the Northeast for the Southwest as they travel to Arizona to take on the Cardinals. The game in the U of Phoenix Stadium in Glendale, AZ is scheduled to kick off at 4:05 PM ET, and will be televised regionally on CBS.

The Bills became another casualty of the San Francisco 49ers, losing 45-3. Buffalo barely showed up in this one, allowing the Niners to set a franchise record with 621 yards of offense. The Bills, on the other hand, could manage just 204 total yards. The 49ers held a 311-89 edge in rushing yards, and kept possession of the ball for 13 more minutes than Buffalo. The Bills also coughed it up twice, losing a fumble and throwing an interception. QB Ryan Fitzpatrick threw 16-of-26, for 126 yards. Over the last two weeks, the Bills have allowed 580 and 621 yards, along with 62 first downs. In the last 6 quarters of play, they have been outscored 90-10.

The Cardinals come into this game off of a tough loss in St. Louis to the Rams, 17-3. This was a 15-point spread loss for AZ. The Rams sacked Cards QB Kevin Kolb 9 times, while not allowing a single touchdown from Arizona. Despite this, the Cardinals won the stats game, holding a 20-12 edge in first downs, and a 282-242 edge in offensive yards. Those 9 sacks cost Arizona 52 yards, with 5 penalties costing them 35 more. QB Kolb threw 28-of-50, for 289 yards. In 3 of their 5 games this season, the Cardinals have tallied fewer than 46 rushing yards.

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Buffalo is 2-3 ATS on the season so far, and 0-2 ATS as the away underdog. The dog is on a 9-1-1 spread run in Arizona games. The Cardinals are 2-16 ATS coming off of a double-digit SU loss against an opponent coming off a similar double-digit SU loss. How's that for a stat? On the season, the Cards are 3-2 ATS, and are 0-1 ATS as a home favorite.

These two teams have met just twice since 2001, with the series tied at a game apiece. Their last meeting, in October 2008, resulted in a 41-17 Cardinals victory. In that one, Arizona was a 1 ½ point favorite. In an October 2004 matchup, Buffalo won 38-14, after the Bills were 4 point favorites.

For this Sunday's game, the Bet Royal Sportsbook odds list the Cardinals as 4 ½ point home favorites. The over/under is set at 43 ½ points.

Listen to the Bills-Cardinals betting trends podcast right here:

Click here to read our Chiefs-Bills odds preview from Week 2 of the regular season. We also looked at the Bills-Jets game in Week 1, which you can read on this page. If you're a Cardinals fan, go here to read our Arizona-New England trends preview from Week 2. We also previewed the Seahawks-Cardinals game from Week 1 in this article.

 

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