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Bet on the NFLIt's So Cal versus No Cal as the San Diego Chargers travel north in the Golden State and meet the San Francisco 49'ers on Thursday to conclude the preseason. The first kickoff in Candlestick Park is scheduled for 10:00 ET.

San Diego (3-0) barely remained unbeaten in this seasons exhibition affairs as they squeaked out a 12-10 win over Minnesota last week. They managed just 4 field goals. However, this was not a great surprise considering QB Philip Rivers and TE Antonio Gates were held out of action. Rivers is probable against the Niners, but RB Ryan Matthews is out. Half of the Chargers offensive line is also hurting, so expect to see the San Fran "D" get after whoever the Charger QB is in this one.

San Francisco (2-1) beat Peyton Manning and the Broncos last week in another game that featured a placekicker for the Niners. David Akers booted 5 field goals in the San Francisco 29-24 victory. Brandon Jacobs sat this one out with a bad knee and WR Ted Ginn Jr. injured an ankle during the contest. Neither is expected to play Thursday.

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These two teams have only met three times since 2001. All three of those meetings resulted in Chargers victories. The last time was in December 2010, where the Chargers buried the 49ers, 34-7 in San Diego.

The Chargers are 3-0 SU on the preseason, and 1-0 SU on the road. They are 3-0 ATS overall, going 1-0 ATS away from home. The 49ers are 2-1 SU on the year, and 1-0 SU at home. They have gone 2-1 ATS overall, and are 1-0 ATS in Candlestick Park.

From Bet Royal's NFL odds, San Francisco is a 3 point favorite by the bay, listed at a -$110. As the favorite, the 49ers are 1-0 ATS overall, and 1-0 ATS as a home favorite. The Chargers are 1-0 ATS as the underdog, and 1-0 ATS as the road dog. The moneyline is also $110/$100 on the under/over of 38 points.

We previewed the Chargers-Vikings Week 3game previously. Click here to go to that article.
We also looked at the Chargers in Week 2 against the Cowboys, which you can read here.


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